| ID | DRAMP29038 |
|---|---|
| Sequence | IKLSKETKKNLKKVLKGAIKGAIAVAKMV |
| Length | 29 |
| Name | [P5K,D9K]Hymenochirin-1B |
| Source | Synthetic construct |
| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anticancer |
| Pathogen | [Ref.24172540] Gram-positive bacteria: S. aureus ATCC 29213 (MIC = 6.25 μM), S. aureus ATCC 25923 (MIC = 3.1 μM), S.epidermidis RP62A (MIC = 1.6 μM), S.epidermidis RP62A/1 (MIC = 1.6 μM), C.albicans ATCC 90028 (MIC = 50 μM);##Gram-negative bacteria: E.coli (MIC = 6.25 μM), A. baumannii (MIC = 3.1 μM), S. maltophilia (MIC = 3.1 μM), K. pneumoniae (MIC = 6.25 μM), P. aeruginosa (MIC = 12.5 μM), P.mirabilis (MIC > 100 μM).##[Ref.30789695] Cancer cell lines: A549 (IC50 = 1.17 ± 0.23 μM), HCT116 (IC50 = 4.93 ± 0.51 μM), HepG2 (IC50 = 2.46 ± 0.32 μM). |
| Hemolytic Activity | [Ref.24172540] LC₅₀ = 127 ± 9 μM against freshly prepared human erythrocytes. |
| Cytotoxicity | No cytotoxicity information found in the reference |
| N-terminal Modification | Free |
| C-terminal Modification | Amidation |
| Linear/Cyclic/Branched | Linear |
| Uniprot | Not found |
| PDB | |
| 3D View | |
| PDB Download | Download PDB Predicted by Alphafold2 |
| PubMed ID | 24172540, 30789695 |
Physicochemical Properties
| Residues | 29 |
|---|---|
| Sequence | IKLSKETKKNLKKVLKGAIKGAIAVAKMV |
| Molecular Weight | 3108.913 |
| Grand Average of Hydropathy | 0.076 |
| Isoelectric Point | 10.544 |
| Charge at pH 7.4 | 7.536 |
| Secondary Structure | Helix: 0.310, Turn: 0.138, Sheet: 0.310 |
| Instability Index | -8.379 |
| Aromaticity | 0 |