Basic Information
| ID | DRAMP29039 |
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| Sequence | IKLSPKTKKNLKKVLKGAIKGAIAVAKMV |
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| Length | 29 |
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| Name | [E6K,D9K]Hymenochirin-1B |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-,
Immunomodulatory, Anti-inflammatory |
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| Pathogen | [Ref.24172540] Gram-positive bacteria: S. aureus ATCC 29213 (MIC = 3.1 μM), S. aureus ATCC 25923 (MIC = 1.6 μM), S.epidermidis RP62A (MIC = 1.6 μM), S.epidermidis RP62A/1 (MIC = 0.8 μM), C.albicans ATCC 90028 (MIC = 50 μM);##Gram-negative bacteria: E.coli (MIC = 3.1 μM), A. baumannii (MIC = 3.1 μM), S. maltophilia (MIC = 1.6 μM), K. pneumoniae (MIC = 3.1 μM), P. aeruginosa (MIC = 6.25 μM), P.mirabilis (MIC > 100 μM). |
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| Hemolytic Activity | [Ref.24172540] LC₅₀ = 85 ± 5 μM against freshly prepared human erythrocytes. |
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| Cytotoxicity | No cytotoxicity information found in the reference |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
Not found |
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| PDB |
|
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 24172540 |
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