Basic Information
| ID | DRAMP29062 |
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| Sequence | FLQRIIGRLGRLF |
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| Length | 13 |
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| Name | GHaR8R (variant of temporin-GHaR) |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal |
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| Pathogen | [Ref.33291521] Gram-positive bacteria: S. aureus(MIC / MBC = 1.6-3.1μM / 3.1μM), B. subtilis(MIC / MBC = 12.5μM / 12.5μM), S. mutans(MIC / MBC = 6.2μM / 6.2μM), MRSA(MIC / MBC = 3.1μM / 3.1μM), MRSA-1(MIC /MBC = 6.2μM / 6.2μM), MRSA-2(MIC / MBC = 3.1μM / 12.5μM), MRSA-3(MIC / MBC = 6.2μM / 12.5μM)##Gram-negative bacteria: E. coli(MIC / MBC = 3.1μM / 3.1μM), D31(MIC /MBC = 12.5μM / 25μM), P. aeruginosa(MIC / MBC > 50μM / 50μM), PAO1(MIC / MBC = 6.2μM / 12.5μM)##Fungi: C. albicans(MIC / MBC = 12.5μM / 12.5μM) |
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| Hemolytic Activity | [Ref.33291521]HL50 = 160μM against human red blood cells (hRBCs) |
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| Cytotoxicity | [Ref.33291521]GHaR6R induced a cell viability of 83%, 64% and 50% to human oral epithelial cells at 3.1μM, 6.2μM and 12.5μM. |
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| N-terminal Modification | Free |
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| C-terminal Modification | Free |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 33291521 |
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