| ID | DRAMP29066 |
|---|---|
| Sequence | GFAWNVCVYRNGVRVCHRRAN |
| Length | 21 |
| Name | Marine peptide-N6 |
| Source | Synthetic construct |
| Activity | Antimicrobial, Antibacterial, Anti-Gram-, Anti-Gram+ |
| Pathogen | [Ref.33348729] Gram-negative bacteria: Edwardsiella tarda(MIC = 6.4 μg/mL), Aeromonas veronii(MIC = 6.4 μg/mL), Escherichia coli CVCC195(MIC = 0.5 μg/mL), E. coli CVCC1515(MIC = 1 μg/mL), E. coli CVCC25922(MIC = 0.25 μg/mL), E. coli CVCCO157(MIC = 0.5 μg/mL), Salmonella typhimurium CVCC533(MIC = 1 μg/mL), S. typhimurium ATCC14028(MIC = 2 μg/mL), S. enteritidis CVCC3377(MIC = 0.25 μg/mL), S. pullorum CVCC1802(MIC = 0.5 μg/mL), S. pullorum CVCC1789(MIC = 0.5 μg/mL), Pseudomonas aeruginosa CICC21630(MIC = 4 μg/mL). ##Gram-positive bacteria: Staphylococcus aureus ATCC43300(MIC = 16 μg/mL), S. aureus ATCC546(MIC = 4 μg/mL), S. aureus ATCC25923(MIC = 0.25 μg/mL), S. hyicus 437-2(MIC = 64 μg/mL), S. hyicus 15095(MIC = 16 μg/mL). |
| Hemolytic Activity | No hemolysis information or data found in the reference(s) presented in this entry |
| Cytotoxicity | [Ref.33348729]Had very low cytotoxicity to mouse peritoneal RAW 264.7 macrophages (cell survival rate >93.35%) |
| N-terminal Modification | Free |
| C-terminal Modification | Free |
| Linear/Cyclic/Branched | Cyclic |
| Uniprot | |
| PDB | 5Y0H |
| 3D View | |
| PDB Download | Download PDB Predicted by Alphafold2 |
| PubMed ID | 33348729 |
Physicochemical Properties
| Residues | 21 |
|---|---|
| Sequence | GFAWNVCVYRNGVRVCHRRAN |
| Molecular Weight | 2477.83 |
| Grand Average of Hydropathy | -0.31 |
| Isoelectric Point | 10.718 |
| Charge at pH 7.4 | 3.542 |
| Secondary Structure | Helix: 0.333, Turn: 0.238, Sheet: 0.095 |
| Instability Index | 41.686 |
| Aromaticity | 0.143 |
