Basic Information

IDDRAMP29066
SequenceGFAWNVCVYRNGVRVCHRRAN
Length21
NameMarine peptide-N6
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram-, Anti-Gram+
Pathogen[Ref.33348729] Gram-negative bacteria: Edwardsiella tarda(MIC = 6.4 μg/mL), Aeromonas veronii(MIC = 6.4 μg/mL), Escherichia coli CVCC195(MIC = 0.5 μg/mL), E. coli CVCC1515(MIC = 1 μg/mL), E. coli CVCC25922(MIC = 0.25 μg/mL), E. coli CVCCO157(MIC = 0.5 μg/mL), Salmonella typhimurium CVCC533(MIC = 1 μg/mL), S. typhimurium ATCC14028(MIC = 2 μg/mL), S. enteritidis CVCC3377(MIC = 0.25 μg/mL), S. pullorum CVCC1802(MIC = 0.5 μg/mL), S. pullorum CVCC1789(MIC = 0.5 μg/mL), Pseudomonas aeruginosa CICC21630(MIC = 4 μg/mL). ##Gram-positive bacteria: Staphylococcus aureus ATCC43300(MIC = 16 μg/mL), S. aureus ATCC546(MIC = 4 μg/mL), S. aureus ATCC25923(MIC = 0.25 μg/mL), S. hyicus 437-2(MIC = 64 μg/mL), S. hyicus 15095(MIC = 16 μg/mL).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity[Ref.33348729]Had very low cytotoxicity to mouse peritoneal RAW 264.7 macrophages (cell survival rate >93.35%)
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedCyclic
Uniprot
PDB 5Y0H
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID33348729

Physicochemical Properties

Residues21
SequenceGFAWNVCVYRNGVRVCHRRAN
Molecular Weight2477.83
Grand Average of Hydropathy-0.31
Isoelectric Point10.718
Charge at pH 7.43.542
Secondary StructureHelix: 0.333, Turn: 0.238, Sheet: 0.095
Instability Index41.686
Aromaticity0.143

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