Basic Information

IDDRAMP29069
SequencekFwSLLkKAlrLwAkVL
Length17
NameCPF-2-2 (Variant of CPF-C1)
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+
Pathogen[Ref.32590058] Gram-positive: S. aureus ATCC 25923 (MIC = 8 μg/mL, MIC = 128 μg/mL in 10% serum, MIC = 8 μg/mL in 150 mM, MBIC50 = 16 μg/mL, MBIC90 = 16 μg/mL, MBEC = 16 μg/mL), MRSA ATCC 33591 (MIC = 8 μg/mL), MRSA 054 isolated from clinics (MIC = 8 μg/mL), MRSA 023 isolated from clinics (MIC = 8 μg/mL), MRSA 113 isolated from clinics (MIC = 8 μg/mL), MRSA 048 isolated from clinics (MIC = 8 μg/mL), MRSA 002 isolated from clinics (MIC = 8 μg/mL), MRSA 074 isolated from clinics (MIC = 8 μg/mL), MRSA 051 isolated from clinics (MIC = 16 μg/mL), MRSA 052 isolated from clinics (MIC = 8 μg/mL), MRSA 075 isolated from clinics (MIC = 8 μg/mL), MRSA 071 isolated from clinics (MIC = 8 μg/mL), MRSA 936 isolated from clinics (MIC = 8 μg/mL), S. aureus 725 (MIC = 16 μg/mL), S. aureus 794 (MIC = 8 μg/mL)
Hemolytic Activity[Ref.32590058]It showed almost no hemolytic activity, even at concentrations up to 128 μg/ml
CytotoxicityNot found
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID32590058

Physicochemical Properties

Residues17
SequencekFwSLLkKAlrLwAkVL
Molecular Weight2100.636
Grand Average of Hydropathy0.406
Isoelectric Point11.334
Charge at pH 7.44.547
Secondary StructureHelix: 0.529, Turn: 0.059, Sheet: 0.412
Instability Index15.841
Aromaticity0.176

Similar Structure Search

Candidates based on structure

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