Basic Information
| ID | DRAMP29079 |
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| Sequence | LAKKIYRAWKRR |
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| Length | 12 |
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| Name | dCATH 12-1 (modified from dCATH 12) |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram-, Anti-Gram+ |
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| Pathogen | [Ref.32698035] Gram-positive bacteria: S. aureus KCTC 1621 (MIC = 4 μM), S. epidermidis KCTC 1917 (MIC = 8 μM), B. subtilis KCTC 3068 (MIC = 8 μM);##Resistant Gram-positive bacteria: MRSA CCARM 3089 (MIC = 32 μM), MRSA CCARM 3090 (MIC = 16 μM), MRSA CCARM 3095 (MIC = 16 μM), VREF ATCC 51559(MIC = 16 μM);##Gram-negative bacteria: E. coli KCTC 1682 (MIC = 8 μM), P. aeruginosa KCTC 1637(MIC = 4 μM), S. typhimurium KCTC 1926 (MIC = 4 μM);##Resistant Gram-negative bacteria: MDRPAd CCARM 2095 (MIC = 32 μM), MDRPA CCARM 2109 (MIC = 32 μM); ##Yeast: C. albicans KCTC 7965 (MIC = 8 μM), C. albicans KCTC 7121 (MIC = 8 μM). |
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| Hemolytic Activity | [Ref.32698035] HC10 > 256 μM. Note: HC10 is the peptide concentration that caused 10% hemolysis of sheep red blood cells (sRBCs). |
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| Cytotoxicity | [Ref.32698035] At the concentration of 1.25, 2.5, 5, 10, 20, 40, 80 μM, the cell survival of dCATH 12-1 against human bone marrow SH-SY5Y cells is 102%, 102%, 100%, 96%, 96%, 78%, 69%. |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 32698035 |
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