Basic Information
| ID | DRAMP29106 |
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| Sequence | RKKRRQRRRLNLKALLAVAKKIL |
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| Length | 23 |
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| Name | t Mastoparan-C(tMP-C, Tat (49-57)-Mastoparan-C) |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-, Anti-cancer,Antifungal |
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| Pathogen | [Ref.29904274]Gram-positive bacteria:Staphylococcus aureus NCTC 10788(MIC=4 µM); Staphylococcus aureus NCTC 10788(MBC=4 µM); Staphylococcus aureus ATCC 12493(MRSA,MIC=4 µM); Staphylococcus aureus ATCC 12493(MRSA,MBC=8 µM); Enterococcus faecalis NCTC 12697(MIC=8 µM); Enterococcus faecalis NCTC 12697(MBC=16 µM);##Gram-negative bacteria:Escherichia coli NCTC 10418(MIC=2 µM); Escherichia coli NCTC 10418(MBC=2 µM); Pseudomonas aeruginosa ATCC 27853(MIC=4 µM); Pseudomonas aeruginosa ATCC 27853(MBC=4 µM);##Fungi:Candida albicans NCTC 1467(MIC=2 µM); Candida albicans NCTC 1467(MBC=2 µM);##Cancer:Human squamous lung carcinoma NCI-H157(IC50=2.79 µM);Human breast adenocarcinoma MDA-MB-435S(IC50=3.86 µM);Human prostate adenocarcinoma PC-3(IC50=3.86 µM);Human glioblastoma U251-MG(IC50=3.36 µM); Human breast adenocarcinoma MCF-7(IC50=3.70 µM). |
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| Hemolytic Activity | [Ref.29904274]50% hemolysis against horse erythrocytes at 77.94 µM. |
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| Cytotoxicity | [Ref.29904274]Cytotoxicity:Human microvascular endothelial cells HMEC-1(IC50=9.18 µM). |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
P01516, Q76PP9 |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 29904274 |
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