Basic Information
| ID | DRAMP21028 |
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| Sequence | ALWKDILKNLLKAALNEINQIVQ |
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| Length | 23 |
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| Name | L10, 11-DPS3 (Derived from dermaseptin-PS3 (DPS3)) |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal |
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| Pathogen | [Ref.30087268]Gram-positive bacteria : Staphylococcuss aureus (NCTC 10788)(MIC=8 μM);##Gram-negative bacteria : Escherichia coli (NCTC 10418)(MIC=16 μM);##Fungi : Candida albicans (NCYC 1467)(MIC=16 μM) |
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| Hemolytic Activity | [Ref.30087268] 20% hemolysis at 0 μM , 70% hemolysis at 1 μM , 95% hemolysis at 2 μM against horse red blood cells |
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| Cytotoxicity | [Ref.30087268] IC50 = 0.12 μM for H157. ##IC50 = 1.85 μM for PC3. ##IC50 = 8.76 μM for HMEC-1 |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 30087268 |
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