Basic Information

IDDRAMP29084
SequenceGVTFNALKGVAKTVAAQLLKTAR
Length23
NameBrevinin-GR23
SourceHylarana guentheri
ActivityAntimicrobial, Antibacterial, Anti-Gram-, Anti-Gram+
Pathogen[Ref.31549575] Gram-positive bacteria: Staphylococcus aureus (MIC = 16 μM), Streptococcus mutans(MIC > 100 μM);##Gram-negative bacteria: Escherichia coli (MIC = 64 μM), Pseudomonas aeruginosa(MIC > 100 μM);##Yeast: Canidia albican (MIC > 100 μM)
Hemolytic Activity[Ref.31549575]B-GR23 induced a hemolysis of 0.13%, 0.23%, 0.38%, 0.75%, 0.83% and 1.60% on human blood red cells at the concentrations of 25, 50, 75, 100, 150 and 200 μM.
CytotoxicityNot found
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID31549575

Physicochemical Properties

Residues23
SequenceGVTFNALKGVAKTVAAQLLKTAR
Molecular Weight2357.793
Grand Average of Hydropathy0.422
Isoelectric Point11.264
Charge at pH 7.43.55
Secondary StructureHelix: 0.304, Turn: 0.130, Sheet: 0.348
Instability Index0.165
Aromaticity0.043

Similar Structure Search

Candidates based on structure

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