Basic Information

IDDRAMP21109
SequenceGIGGALLSAKAALGLAKGLAEHFAN
Length25
NameFPA-Bombinin-BO (toads, amphibians, animals)
SourceAsian bombinid toad species, Bombina orientalis
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.25056849] Gram-positive bacteria : Staphylococcus aureus(MIC=7 μM, MBC=14 μM);##Gram-negative bacteria : Escherichia coli(MIC=14 μM, MBC=14 μM);##Fungi : Candida albicans(MIC=7 μM, MBC=14 μM)
Hemolytic Activity[Ref.25056849] 100% hemolysis at 125 mg/L against horse red blood cells
Cytotoxicity[Ref.25056849] No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID25056849

Physicochemical Properties

Residues25
SequenceGIGGALLSAKAALGLAKGLAEHFAN
Molecular Weight2350.714
Grand Average of Hydropathy0.724
Isoelectric Point8.598
Charge at pH 7.40.59
Secondary StructureHelix: 0.280, Turn: 0.280, Sheet: 0.520
Instability Index-2.816
Aromaticity0.04

Similar Structure Search

Candidates based on structure

Address: No.2699 Qianjin Street, Changchun City, China. Zip Code: 130012. 苏ICP备2021057230号-1.