Basic Information

IDDRAMP01910
SequenceGVITDALKGAAKTVAAELLRKAHCKLTNSC
Length30
NameBrevinin-2GHb (AMP-2; Frogs, amphibians, animals)
SourceRana guentheri (Gunther's frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
PathogenGram-positive bacteria: Staphylococcus aureus FDA209P (MIC=16.5 µg/ml), Bacillus subtilis ATCC 6633 (MIC>64 µg/ml);##Gram-negative bacteria: Escherichia coli O111 (MIC=8.2 µg/ml), Escherichia coli ATCC 25922 (MIC=8.2 µg/ml).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys24 and Cys30)
Linear/Cyclic/BranchedCyclic
Uniprot A0AEI5
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID16979798

Physicochemical Properties

Residues30
SequenceGVITDALKGAAKTVAAELLRKAHCKLTNSC
Molecular Weight3083.628
Grand Average of Hydropathy0.213
Isoelectric Point9.307
Charge at pH 7.42.537
Secondary StructureHelix: 0.233, Turn: 0.133, Sheet: 0.367
Instability Index7.793
Aromaticity0

Similar Structure Search

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