Basic Information
| ID | DRAMP29128 |
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| Sequence | GNLKKLLAVAKKIL |
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| Length | 14 |
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| Name | Mastoparan-C [L1G, A5K] |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram- |
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| Pathogen | [Ref.33285267]Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=16 µM); Bacillus subtilis ATCC 23857(MIC=4 µM);##Gram-negative bacteria:Escherichia coli ATCC 25922(4.5 mM KCl and 0.004 mM FeCl3,MIC=4 µM); Pseudomonas aeruginosa ATCC 9027(0.004 mM FeCl3,MIC=4 µM); Klebsiella pneumoniae ATCC 700603(MIC=16 µM); Escherichia coli ATCC 25922(150mM NaCl,MIC=16 µM); Escherichia coli ATCC 25922(1mM MgCl2,MIC=8 µM); Pseudomonas aeruginosa ATCC 9027(NaCl/MgCl2=150mM/1mM,MIC=32 µM); Pseudomonas aeruginosa ATCC 9027(4.5mM KCl,MIC=16 µM); Escherichia coli(Rifampin-resistant strain,MIC=4 µM). |
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| Hemolytic Activity | [Ref.33285267]0% hemolysis against mouse erythrocytes at 256 µM. |
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| Cytotoxicity | [Ref.33285267]65% Killing against Human embryonic kidney HEK293T cells at 128 µM; Human embryonic kidney HEK293T cells(IC50=128 µM). |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
P01516 |
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| PDB |
|
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 33285267 |
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