Basic Information

IDDRAMP01628
SequenceGWMSKIASGIGTFLSGMQQ
Length19
NamePhylloxin (Frogs, amphibians, animals)
SourcePhyllomedusa bicolor (Two-colored leaf frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
PathogenGram-negative bacteria: Acholeplasma laidlawii A-PG8 (MIC=12.5 µM), Spiroplasma melliferum BC3 (MIC=50 µM), Rhizobium meliloti 102F34 (MIC=12.5 µM), Escherichia coli K12 (MIC=10 µM);##Gram-positive bacteria: Bacillus megaterium KM (MIC=3.12 µM), Corynebacterium glutamicum ATCC 27853 (MIC=1.56 µM), Micrococcus luteus ATCC 27853 (MIC=3.0 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity[Ref.10632707]No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot P81565, Q9PT74
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID10632707

Physicochemical Properties

Residues19
SequenceGWMSKIASGIGTFLSGMQQ
Molecular Weight1999.313
Grand Average of Hydropathy0.247
Isoelectric Point8.75
Charge at pH 7.40.555
Secondary StructureHelix: 0.263, Turn: 0.368, Sheet: 0.211
Instability Index50.816
Aromaticity0.105

Similar Structure Search

Candidates based on structure

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