Basic Information

IDDRAMP01776
SequenceFLPIVTNLLSGLLGK
Length15
NameTemporin-1Sb (Temporin-SHb; Frogs, amphibians, animals)
SourcePelophylax saharicus (Sahara frog) (Rana saharica)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.18584916]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=58 µM), Enterococcus faecalis ATCC 29212 (MIC>116 µM), Bacillus megaterium (MIC=46 µM);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=231 µM), Escherichia coli ATCC 35218 (MIC>116 µM);##Fungi: Aspergillus flavus (MIC=58 µM).
Hemolytic Activity[Ref:18584916]LC50>116 μM against human erythrocytes
Cytotoxicity[Ref.18584916]No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot B3KYH5
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID18584916

Physicochemical Properties

Residues15
SequenceFLPIVTNLLSGLLGK
Molecular Weight1584.94
Grand Average of Hydropathy1.28
Isoelectric Point8.75
Charge at pH 7.40.555
Secondary StructureHelix: 0.533, Turn: 0.333, Sheet: 0.333
Instability Index-4.827
Aromaticity0.067

Similar Structure Search

Candidates based on structure

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