Basic Information

IDDRAMP21415
SequenceLKKWWKTSKGLLGGLLGKVTSVIK
Length24
Nameα4-short (Derived from α4)
Sourcesynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.30967458] Gram-positive bacteria: Staphylococcus aureus 467-1 (MIC=2μM), Staphylococcus aureus 0154-17 (MIC=2μM), Staphylococcus aureus 187-10 (MIC=16μM), Staphylococcus aureus 0194-19 (MIC=2μM), Staphylococcus aureus US300 (MIC=8μM), Staphylococcus aureus 122-12 (MIC=2μM), Enterococcus faecium 23614 (MIC=1μM), Enterococcus faecium 14678 (MIC=1μM), Enterococcus faecium 26125 (MIC=1μM);##Gram-negative bacteria:Pseudomonas aeruginosa 16-21 (MIC=2μM), Pseudomonas aeruginosa 16-72 (MIC=2μM), Pseudomonas aeruginosa 16-73 (MIC=2μM), Pseudomonas aeruginosa 0038-13 (MIC=2μM), Pseudomonas aeruginosa 0038-14 (MIC=1μM), Pseudomonas aeruginosa 0040-21 (MIC=2μM), Pseudomonas aeruginosa 0046-106 (MIC=8μM), Pseudomonas aeruginosa 0068-37 (MIC=16μM), Pseudomonas aeruginosa 0071-75 (MIC=2μM), Pseudomonas aeruginosa 97-5 (MIC=2μM), Pseudomonas aeruginosa 109-10 (MIC=2μM), Pseudomonas aeruginosa 16-21 (MIC=2μM)Pseudomonas aeruginosa 132-37 (MIC=2μM), Pseudomonas aeruginosa 129-5 (MIC=2μM), Pseudomonas aeruginosa 152-19 (MIC=2μM), Pseudomonas aeruginosa 159-30 (MIC=2μM), Pseudomonas aeruginosa 474-1 (MIC=2μM), Acinetobacter baumannii C3 (MIC=1μM), Acinetobacter baumannii D4 (MIC=2μM), Acinetobacter baumannii A2 (MIC=4μM), Escherichia coli YDC518 (MIC=1μM), Escherichia coli YDC575 (MIC=2μM), Escherichia coli YDC596 (MIC=1μM), Escherichia coli YDC107 (MIC=1μM), Escherichia coli YDC337 (MIC=1μM), Escherichia coli YDC748 (MIC=1μM), Klebsiella pneumoniae A2 (MIC=4μM), Klebsiella pneumoniae D4 (MIC=2μM), Klebsiella pneumoniae 438-16 (MIC=4μM)
Hemolytic Activity[Ref.30967458] 1% hemolysis at 17 μM, 2% hemolysis at 30 μM, 3% hemolysis at 63 μM against human red blood cells
Cytotoxicity[Ref.30967458] The white blood cell toxicity of α4-short is ~0%, ~0%, ~0%, ~0%, ~0%, 1.8% and 3.1% at peptide concentrations of 1, 2, 4, 8, 16, 32 and 64 μM.
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID30967458

Physicochemical Properties

Residues24
SequenceLKKWWKTSKGLLGGLLGKVTSVIK
Molecular Weight2641.244
Grand Average of Hydropathy0.087
Isoelectric Point10.699
Charge at pH 7.45.542
Secondary StructureHelix: 0.417, Turn: 0.250, Sheet: 0.208
Instability Index-6.5
Aromaticity0.083

Similar Structure Search

Candidates based on structure

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