Basic Information

IDDRAMP01546
SequenceSLWETIKNAGKGFIQNLDKIR
Length21
NameNigroain-K1 (Frogs, amphibians, animals)
SourceRana nigrovittata (Black-striped frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.19778602]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=9.38 µg/ml), Bacillus subtilis (MIC=21.88 µg/ml);##Gram-negative bacterium: Escherichia coli ML-35P (MIC=37.50 µg/ml);##Yeast: Candida albicans ATCC2002 (MIC=32.74 µg/ml).
Hemolytic Activity[Ref:19778602]22.49 ± 4.8% hemolytic activity at 100 µg/ml against rabbit red cells
Cytotoxicity[Ref.19778602]No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID19778602

Physicochemical Properties

Residues21
SequenceSLWETIKNAGKGFIQNLDKIR
Molecular Weight2431.787
Grand Average of Hydropathy-0.533
Isoelectric Point9.697
Charge at pH 7.41.247
Secondary StructureHelix: 0.333, Turn: 0.238, Sheet: 0.190
Instability Index0.586
Aromaticity0.095

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