Basic Information

IDDRAMP03190
SequenceRLGNFFRKAKKKIGRGLKKIGQKIKDFLGNLVPRTES
Length37
NamePobRL-37 (cathelicidin; primates, mammals, animals)
SourceCercopithecidae
ActivityAntimicrobial, Antibacterial, Antifungal
PathogenIn 20% TSB in SPB medium: Escherichia coli (MIC=0.5 µM), Pseudomonas aeruginosa (MIC=0.5-1 µM), Staphylococcus aureus (MIC=2 µM), Enterococcus faecalis (MIC=2-4 µM).##In 20% SAB in SPB: Candida albicans (MIC=8-16 µM). In 5% TSB in SPB: Escherichia coli (MIC=0.5 µM). In 5% SAB in SPB: Candida albicans (MIC=4-8 µM).##In 20% TSB in PIL: Escherichia coli (MIC=1 µM), Pseudomonas aeruginosa (MIC=1-2 µM); Staphylococcus aureus (MIC=0.5 µM), Enterococcus faecalis (MIC=1-2 µM).##In 20% SAB in PIL: Candida albicans (MIC=16 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID16720578

Physicochemical Properties

Residues37
SequenceRLGNFFRKAKKKIGRGLKKIGQKIKDFLGNLVPRTES
Molecular Weight4243.059
Grand Average of Hydropathy-0.776
Isoelectric Point11.625
Charge at pH 7.49.539
Secondary StructureHelix: 0.297, Turn: 0.243, Sheet: 0.162
Instability Index-1.149
Aromaticity0.081

Similar Structure Search

Candidates based on structure

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