Basic Information

IDDRAMP02727
SequenceSLGNFFRKARKKIGEEFKRIVQRIKDFLQHLIPRTEA
Length37
NameHmdSL-37 (cathelicidin; primates, mammals, animals)
SourceHylobates sp. (Gibbon)
ActivityAntimicrobial, Antibacterial, Antifungal
PathogenIn 20% TSB in SPB medium Escherichia coli (MIC=2 µM), Pseudomonas aeruginosa (MIC=8 µM), Staphylococcus aureus (MIC>32 µM), Enterococcus faecalis (MIC=8 µM).##In 20% SAB in SPB Candida albicans (MIC>32 µM). In 5% SAB in SPB Candida albicans (MIC=8 µM). In 20% SAB in PIL Candida albicans (MIC>32 µM).##In 5% TSB in SPB Escherichia coli (MIC=1 µM), Pseudomonas aeruginosa (MIC=2 µM), Staphylococcus aureus (MIC=2 µM).##In 20% TSB in PIL Escherichia coli (MIC>32 µM), Pseudomonas aeruginosa (MIC=16-32 µM); Staphylococcus aureus (MIC=8-16 µM), Enterococcus faecalis (MIC>32 µM).##In 50% MH in SPB medium Escherichia coli (MIC>32 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID16720578

Physicochemical Properties

Residues37
SequenceSLGNFFRKARKKIGEEFKRIVQRIKDFLQHLIPRTEA
Molecular Weight4471.219
Grand Average of Hydropathy-0.681
Isoelectric Point11
Charge at pH 7.45.281
Secondary StructureHelix: 0.324, Turn: 0.135, Sheet: 0.216
Instability Index17.173
Aromaticity0.108

Similar Structure Search

Candidates based on structure

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