Basic Information

IDDRAMP03406
SequenceISRLAGLLRKGGEKIGEKLKKIGQKIKNFFQKLVPQPE
Length38
NamemCRAMP-2 (mouse cathelin-related antimicrobial peptide 2; cathelicidin; Rodents, mammals, animals
SourceMus musculus (Mouse)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1 µM), Escherichia coli ML35 (MIC=2 µM), Escherichia coli D21 (MIC=8 µM), Pseudomonas aeruginosa ATCC 27853 (MIC=4 µM), Serratia marcescens ATCC 8100 (MIC=4 µM);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=32 µM), Staphylococcus aureus Cowan I (MIC=32 µM), Staphylococcus aureus (MRSA) (MIC>64 µM), Staphylococcus aureus (MRSA) (MIC=64 µM), Staphylococcus epidermidis ATCC 12228 (MIC=16 µM), Streptococcus faecalis ATCC 29212 (MIC=32 µM), Bacillus megaterium Bm11 (MIC=4 µM).##Fungi: Candida albicans (MIC>64 µM), Cryptococcus neoformans (MIC=16 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P51437, Q0VB78
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID9148921, 8706928

Physicochemical Properties

Residues38
SequenceISRLAGLLRKGGEKIGEKLKKIGQKIKNFFQKLVPQPE
Molecular Weight4291.136
Grand Average of Hydropathy-0.582
Isoelectric Point10.461
Charge at pH 7.46.543
Secondary StructureHelix: 0.316, Turn: 0.237, Sheet: 0.237
Instability Index17.103
Aromaticity0.053

Similar Structure Search

Candidates based on structure

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