Basic Information

IDDRAMP01791
SequenceFLPLVTMLLGKLF
Length13
NameTemporin-1Vc (Temporin 1Vc; Frogs, amphibians, animals)
SourceRana virgatipes (Ranidae) (Aquarana)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.15996769]Gram-positive bacteria: Staphylococcus aureus NCTC8325 (MIC=5 µM), S. aureus (MRSA) T7/20 (MIC=10 µM), S. epidermidis RP62A (MIC=10 µM), Enterococcus faecalis ATCC 29212 (MIC=40 µM), Streptococcus group B HNTCC 80130 (MIC=40 µM);##Gram-negative bacteria: Klebsiella pneumoniae KK3 9904 (MIC=80 µM), Pseudomonas aeruginosa ATCC 27853 (MIC=160 µM), Enterobacter cloacae HNTCC 53001 (MIC=40 µM).
Hemolytic Activity[Ref:15996769]LD50=30 μM against washed human erythrocytes
Cytotoxicity[Ref.15996769]No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID15996769

Physicochemical Properties

Residues13
SequenceFLPLVTMLLGKLF
Molecular Weight1491.921
Grand Average of Hydropathy1.854
Isoelectric Point8.75
Charge at pH 7.40.555
Secondary StructureHelix: 0.615, Turn: 0.154, Sheet: 0.462
Instability Index4.454
Aromaticity0.154

Similar Structure Search

Candidates based on structure

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