Basic Information

IDDRAMP01832
SequenceFLPGLLAGLL
Length10
NameTemporin-Eca (Frogs, amphibians, animals)
SourceEuphlyctis cyanophlyctis (Skittering frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Swiss_Prot Entry C0HJB9]Gram-negative bacteria: Escherichia coli HP101BA (MIC=12.3 µM), Klebsiella pneumoniae PTCC1388 (MIC=9.8 µM);##Gram-positive bacteria: Micrococcus luteus PTCC1625 (MIC=8.3 µM), Staphylococcus aureus PTCC1431 (MIC=10.6 µM).
Hemolytic Activity[Ref.Int J Pept Res Ther(2012)18;107.]<3% hemolytic activity at 60 µg/ml against human red blood cells
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot C0HJB9
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed IDPubMed ID is not available

Physicochemical Properties

Residues10
SequenceFLPGLLAGLL
Molecular Weight1013.273
Grand Average of Hydropathy2.12
Isoelectric Point5.525
Charge at pH 7.4-0.443
Secondary StructureHelix: 0.600, Turn: 0.300, Sheet: 0.600
Instability Index28.26
Aromaticity0.1

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