Basic Information

IDDRAMP01968
SequenceFLPIIAGAAAKVVEKIFCAISKKC
Length24
NameBrevinin-1Yc (Frogs, amphibians, animals)
SourceLithobates yavapaiensis (North American leopard frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.19254736] Gram-positive bacteria : Staphylococcus aureus(MIC=6 μM);##Gram-negative bacteria : Escherichia coli(MIC=100 μM);##Fungi : Candida albicans(MIC=6 μM)Gram-negative bacterium: Escherichia coli (MIC=100 µM);##Gram-positive bacterium: Staphylococcus aureus (MIC=6 µM).##Yeast: Candida albicans (MIC=6 µM).##cancer cells HepG2 (LC50=14 µM).
Hemolytic Activity[Ref.19254736] LC50=13 μM against human red blood cells
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID19254736

Physicochemical Properties

Residues24
SequenceFLPIIAGAAAKVVEKIFCAISKKC
Molecular Weight2521.135
Grand Average of Hydropathy1.163
Isoelectric Point9.308
Charge at pH 7.42.5
Secondary StructureHelix: 0.375, Turn: 0.125, Sheet: 0.292
Instability Index6.996
Aromaticity0.083

Similar Structure Search

Candidates based on structure

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