Basic Information

IDDRAMP01978
SequenceKLKNFAIGVAQSLLNKASCKLSGQC
Length25
NameBrevinin-2R (Frogs, amphibians, animals)
SourcePelophylax ridibundus (Marsh frog) (Rana ridibunda)
ActivityAntimicrobial, Antibacterial, Anti-cancer
Pathogen[Swiss_Prot Entry P85095]Cytotoxic to cancer cells, acts via the activation of the lysosomal-mitochondrial death pathway and autophagy-like cell death
Hemolytic Activity[Ref.18494941]2.5% hemolytic activity at 200 μg/ml against sheep erythrocytes
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P85095
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID18494941

Physicochemical Properties

Residues25
SequenceKLKNFAIGVAQSLLNKASCKLSGQC
Molecular Weight2622.115
Grand Average of Hydropathy0.172
Isoelectric Point9.701
Charge at pH 7.43.498
Secondary StructureHelix: 0.280, Turn: 0.280, Sheet: 0.280
Instability Index30.472
Aromaticity0.04

Similar Structure Search

Candidates based on structure

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