Basic Information

IDDRAMP02228
SequenceSMLSVLKNLGKVGLGFVACKINKQC
Length25
NameRANATUERIN 1 (Frogs, amphibians, animals)
SourceLithobates catesbeiana (American bullfrog) (Rana catesbeiana)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.9784389] Gram-positive bacterium: Staphylococcus aureus (MIC=50 µM);##Gram-negative bacterium: Escherichia coli (MIC=2 µM);##Yeast: Candida albicans (MIC=70 µM).
Hemolytic Activity[Ref.9784389] It has no detectable hemolytic activity at aconcentration of 20µg/ml against human red blood cell.
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys19 and Cys25)
Linear/Cyclic/BranchedCyclic
Uniprot P82741
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID9784389

Physicochemical Properties

Residues25
SequenceSMLSVLKNLGKVGLGFVACKINKQC
Molecular Weight2651.262
Grand Average of Hydropathy0.596
Isoelectric Point9.7
Charge at pH 7.43.194
Secondary StructureHelix: 0.360, Turn: 0.280, Sheet: 0.240
Instability Index26.108
Aromaticity0.04

Similar Structure Search

Candidates based on structure

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