Basic Information

IDDRAMP02041
SequenceLPFVAGVAAEMMQHVYCAASKKC
Length23
NameBrevinin-1-OR1 (Frogs, amphibians, animals)
SourceOdorrana rotodora (Chinese odorous frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.3 µg/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=42.4 µg/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=10.6 µg/ml).##Yeast: Candida albicans (MIC=10.6 µg/ml).
Hemolytic Activity[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 μg/mL.
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys17 and Cys23)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22029824

Physicochemical Properties

Residues23
SequenceLPFVAGVAAEMMQHVYCAASKKC
Molecular Weight2454.951
Grand Average of Hydropathy0.648
Isoelectric Point8.043
Charge at pH 7.40.539
Secondary StructureHelix: 0.261, Turn: 0.130, Sheet: 0.391
Instability Index18.504
Aromaticity0.087

Similar Structure Search

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