Basic Information

IDDRAMP02050
SequenceLAFVAGVAAEMMQHVYCAASKKC
Length23
NameBrevinin-1-OR11 (Frogs, amphibians, animals)
SourceOdorrana rotodora (Chinese odorous frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.2 µg/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=12.4 µg/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=12.4 µg/ml).##Yeast: Candida albicans (MIC=12.4 µg/ml).
Hemolytic Activity[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 μg/mL.
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys17 and Cys23)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22029824

Physicochemical Properties

Residues23
SequenceLAFVAGVAAEMMQHVYCAASKKC
Molecular Weight2428.914
Grand Average of Hydropathy0.796
Isoelectric Point8.043
Charge at pH 7.40.539
Secondary StructureHelix: 0.261, Turn: 0.087, Sheet: 0.435
Instability Index1.757
Aromaticity0.087

Similar Structure Search

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