Basic Information

IDDRAMP02038
SequenceVIVFVASVAAEMMQHVYCAASKKC
Length24
NameBrevinin-1-OA1 (Frogs, amphibians, animals)
SourceOdorrana andersonii (Chinese odorous frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=12.4 µg/ml);##Gram-negative bacteria: Bacillus pyocyaneus CMCCB 10104 (MIC=12.4 µg/ml), Escherichia coli ATCC 25922 (MIC=6.2 µg/ml).##Yeast: Candida albicans (MIC=24.8 µg/ml).
Hemolytic Activity[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 μg/mL.
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys18 and Cys24)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22029824

Physicochemical Properties

Residues24
SequenceVIVFVASVAAEMMQHVYCAASKKC
Molecular Weight2586.124
Grand Average of Hydropathy1.05
Isoelectric Point8.016
Charge at pH 7.40.504
Secondary StructureHelix: 0.333, Turn: 0.083, Sheet: 0.333
Instability Index-1.437
Aromaticity0.083

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