Basic Information

IDDRAMP02044
SequenceILPFVAGVAAEMMKHVYCAASKKC
Length24
NameBrevinin-1-OR5 (Frogs, amphibians, animals)
SourceOdorrana rotodora (Chinese odorous frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-negative bacteria: Escherichia coli ATCC 25922 (MIC=15.2 µg/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=30.4 µg/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=15.2 µg/ml).##Yeast: Candida albicans (MIC=7.6 µg/ml).
Hemolytic Activity[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 μg/mL.
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys18 and Cys24)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22029824

Physicochemical Properties

Residues24
SequenceILPFVAGVAAEMMKHVYCAASKKC
Molecular Weight2568.152
Grand Average of Hydropathy0.792
Isoelectric Point8.822
Charge at pH 7.41.536
Secondary StructureHelix: 0.292, Turn: 0.125, Sheet: 0.375
Instability Index29.317
Aromaticity0.083

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