Basic Information

IDDRAMP02114
SequenceAWLDKLKSLGKVVGKVALGVAQNYLNPQQ
Length29
NameRaniseptin-1 (Rsp-1; Frogs, amphibians, animals)
SourceHypsiboas raniceps (Chaco tree frog) (Hyla roeschmanni)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.18976634]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5 µM), Pseudomonas aeruginosa ATCC 27853 (MIC=10 µM), Xanthomonas citri (MIC<2 µM);##Gram-positive bacterium: Staphylococcus aureus ATCC 29313 (MIC=20 µM).
Hemolytic Activity[Ref.18976634]20% hemolytic activity at 80 μM against human red blood cells
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P86037
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID18976634

Physicochemical Properties

Residues29
SequenceAWLDKLKSLGKVVGKVALGVAQNYLNPQQ
Molecular Weight3138.66
Grand Average of Hydropathy-0.041
Isoelectric Point9.826
Charge at pH 7.42.596
Secondary StructureHelix: 0.379, Turn: 0.241, Sheet: 0.276
Instability Index2.779
Aromaticity0.069

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Candidates based on structure

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