Basic Information

IDDRAMP02219
SequenceGILSSFKGVAKGVAKNLAGKLLDELKCKITGC
Length32
NameRanatuerin-2AUa (Frogs, amphibians, animals)
SourceRana aurora aurora (Northern red-legged frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.15325526]Gram-negative bacteria: Escherichia coli (MIC=5 µM), Pseudomonas aeruginosa (MIC=5 µM), Enterobacter cloacae (MIC=5 µM), Klebsiella pneumoniae (MIC=10 µM), P. mirabilis (MIC>40 µM);##Gram-positive bacteria: Staphylococcus aureus (MIC=20 µM), Staphylococcus epidermidis (MIC=20 µM), Enterococcus faecalis (MIC>40 µM), Streptococcus Group B (MIC=20 µM);##Yeast: Candida albicans (MIC>40 µM)
Hemolytic Activity[Ref.15325526]HC50=290 μM against human erythrocytes
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID15325526

Physicochemical Properties

Residues32
SequenceGILSSFKGVAKGVAKNLAGKLLDELKCKITGC
Molecular Weight3262.927
Grand Average of Hydropathy0.356
Isoelectric Point9.514
Charge at pH 7.43.495
Secondary StructureHelix: 0.312, Turn: 0.250, Sheet: 0.281
Instability Index-4.197
Aromaticity0.031

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Candidates based on structure

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