Basic Information

IDDRAMP02272
SequenceGMASKAGAIAGKIAKVALKAL
Length21
NamePGLa (chain of PYLa/PGLa A; Frogs, amphibians, animals)
SourceXenopus laevis (African clawed frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-negative bacteria: Escherichia coli 25922 (MIC=62-125 µg/ml), Klebsiella pneumoniae 13883 (MIC=250-500 µg/ml), Pseudomonas aeruginosa 27853 (MIC=250-500 µg/ml);##Gram-positive bacteria: Staphylococcus aureus 29213 (MIC=125-500 µg/ml), Strepococcus faecalis (MIC>500 µg/ml).##Yeast: Candida albicans 14053 (MIC=250-500 µg/ml).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot Q99134, B7ZSG6, Q91826
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID3606567, 1717472

Physicochemical Properties

Residues21
SequenceGMASKAGAIAGKIAKVALKAL
Molecular Weight1969.438
Grand Average of Hydropathy0.843
Isoelectric Point10.478
Charge at pH 7.43.547
Secondary StructureHelix: 0.238, Turn: 0.190, Sheet: 0.476
Instability Index-4.814
Aromaticity0

Similar Structure Search

Candidates based on structure

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