Basic Information

IDDRAMP02330
SequenceFFHHIFRGIVHVGKTIHRLVTG
Length22
NamePiscidin-1 (Pis-1; Piscidin 1; fish, chordates, animals)
SourceMorone saxatilis (Striped bass)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.11713517]Gram-positive bacteria: Enterococcus faecalis VRE (MIC=5-10 µM), E. faecalis (MIC=2.5-5 µM), Listeria monocytogenes (MIC=2.5-5 µM), Micrococcus luteus (MIC=10-20 µM), Staphylococcus aureus MRSA (MIC=1.25-2.5 µM), S. epidermitis (MIC=5-10 µM), S. saprophiticus (MIC=5-10 µM), Staphylococcus xylosus (MIC>20 µM), S. agalactiae (MIC=1.25-2.5 µM), S. bovis (MIC=1.25-2.5 µM), S. equisimilis (MIC=2.5-5 µM), S. mitis (MIC=1.25-2.5 µM), S. Pneumonae (MIC=1.25-2.5 µM), S. pyrogenes (MIC=1.25-2.5 µM), Streptococcus iniae KST740 ak (MIC=1.25-2.5 µM), S. iniae KSTSi 6P (MIC=1.25-2.5 µM);##Gram-negative bacteria: Aeromonas hydrophila (MIC>20 µM), Burkholderia cepacia (MIC>20 µM), Vibrio Cholera (MIC=2.5-5 µM), Escherichia coli (MIC=5-10 µM), Enterobacter cloacae (MIC=10-20 µM), E. Aerogenes (MIC=10-20 µM), Klebsiella pneumoniae (MIC=2.5-5 µM), K. oxytoca (MIC=5-10 µM), Salmonella choleraesuis (MIC=10-20 µM), S. typhimurium (MIC=10-20 µM), S. arizonae (MIC=10-20 µM), Serratia marcescens (MIC>20 µM), Shigella flexneri (MIC=2.5-5 µM), S. sonnei (MIC=5-10 µM), Yersinia enterocolitica (MIC=2.5-5 µM); Fungi: Neurospora crassa (MIC=1.56-3.12 µM), A. fumigatus (MIC=50-100 µM), F. axysporum (MIC=0.78-1.56 µM), F. culmorum (MIC=0.39-0.78 µM), C. ablicans (MIC=10-20 µM), C. glabrata (MIC=10-20 µM), C. lusitania (MIC=10-20 µM), C. tropacalis (MIC=10-20 µM).
Hemolytic Activity[Ref.11713517]10% hemolytic activity at 5 μg/mL, 60% hemolytic activity at 10 μg/mL, 100% hemolytic activity at 50 μg/mL against human erythrocytes
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot Q8UUG0
PDB 2JOS, 2OJM
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID11713517

Physicochemical Properties

Residues22
SequenceFFHHIFRGIVHVGKTIHRLVTG
Molecular Weight2572.023
Grand Average of Hydropathy0.455
Isoelectric Point12
Charge at pH 7.42.701
Secondary StructureHelix: 0.455, Turn: 0.136, Sheet: 0.045
Instability Index8.114
Aromaticity0.136

Similar Structure Search

Candidates based on structure

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