Basic Information

IDDRAMP20902
SequenceFIHHIIGGLFSVGKHIHSLIHRRRR
Length25
NameVHSH
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Antifungal
Pathogen[Ref.29040295] Gram-positive bacteria: Staphylococcus aureus (MIC=16 μg/ml; MBC=16 μg/ml), Methicillin-resistant Staphylococcus aureus (MIC=16 μg/ml; MBC=32 μg/ml);##Fungi: Candida albicans (MIC=128 μg/ml; MBC=128 μg/ml)
Hemolytic Activity[Ref.29040295] 5% haemolysis at 1.56 μg/ml, 5% haemolysis at 3.13 μg/ml, 10% haemolysis at 6.25 μg/ml, 35% haemolysis at 12.50 μg/ml, 55% haemolysis at 25.00 μg/ml, 85% haemolysis at 50.00 μg/ml against mouse red blood cells
Cytotoxicity[Ref.29040295] No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID29040295

Physicochemical Properties

Residues25
SequenceFIHHIIGGLFSVGKHIHSLIHRRRR
Molecular Weight2987.517
Grand Average of Hydropathy-0.032
Isoelectric Point12
Charge at pH 7.44.738
Secondary StructureHelix: 0.400, Turn: 0.200, Sheet: 0.080
Instability Index126.44
Aromaticity0.08

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