Basic Information

IDDRAMP20893
SequenceFIHHIIGGLFSAGKAAHRLIRRRRR
Length25
NameI16A
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.29040295] Gram-positive bacteria: Staphylococcus aureus (MIC=64 μg/ml; MBC=128 μg/ml), Methicillin-resistant Staphylococcus aureus (MIC=64 μg/ml; MBC=512 μg/ml);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=256 μg/ml; MBC>512 μg/ml);##Fungi: Candida albicans (MIC=128 μg/ml; MBC=128 μg/ml)
Hemolytic Activity[Ref.29040295] 10% haemolysis at 6.25 μg/ml, 20% haemolysis at 12.50 μg/ml, 35% haemolysis at 25.00 μg/ml, 80% haemolysis at 50.00 μg/ml, 95% haemolysis at 100.00 μg/ml, 100% haemolysis at 200.00 μg/ml against mouse red blood cells
Cytotoxicity[Ref.29040295] No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID29040295

Physicochemical Properties

Residues25
SequenceFIHHIIGGLFSAGKAAHRLIRRRRR
Molecular Weight2939.478
Grand Average of Hydropathy-0.236
Isoelectric Point12
Charge at pH 7.46.665
Secondary StructureHelix: 0.320, Turn: 0.160, Sheet: 0.200
Instability Index121.904
Aromaticity0.08

Similar Structure Search

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