Basic Information

IDDRAMP20904
SequenceFIHHIIGGLFSAGKAIHSLIHRRRR
Length25
NameR18S/R21H
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.29040295] Gram-positive bacteria: Staphylococcus aureus (MIC=32 μg/ml; MBC=64 μg/ml), Methicillin-resistant Staphylococcus aureus (MIC=32 μg/ml; MBC=32 μg/ml);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=256 μg/ml; MBC=512 μg/ml);##Fungi: Candida albicans (MIC=256 μg/ml; MBC=512 μg/ml)
Hemolytic Activity[Ref.29040295] 8% haemolysis at 6.25 μg/ml, 10% haemolysis at 12.50 μg/ml, 15% haemolysis at 25.00 μg/ml, 40% haemolysis at 50.00 μg/ml, 80% haemolysis at 100.00 μg/ml, 100% haemolysis at 200.00 μg/ml against mouse red blood cells
Cytotoxicity[Ref.29040295] No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID29040295

Physicochemical Properties

Residues25
SequenceFIHHIIGGLFSAGKAIHSLIHRRRR
Molecular Weight2893.403
Grand Average of Hydropathy0.072
Isoelectric Point12
Charge at pH 7.44.701
Secondary StructureHelix: 0.360, Turn: 0.200, Sheet: 0.160
Instability Index112.26
Aromaticity0.08

Similar Structure Search

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