Basic Information

IDDRAMP20892
SequenceFIAAIIGGLFSAGKAIHRLIRRRRR
Length25
NameH3A/H4A
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Antifungal
Pathogen[Ref.29040295] Gram-positive bacteria: Staphylococcus aureus (MIC=32 μg/ml; MBC=32 μg/ml), Methicillin-resistant Staphylococcus aureus (MIC=128 μg/ml; MBC=256 μg/ml);##Fungi: Candida albicans (MIC=512 μg/ml; MBC=512 μg/ml)
Hemolytic Activity[Ref.29040295] 7% haemolysis at 1.56 μg/ml, 10% haemolysis at 3.13 μg/ml, 70% haemolysis at 6.25 μg/ml, 95% haemolysis at 12.50 μg/ml, 98% haemolysis at 25.00 μg/ml, 100% haemolysis at 50.00 μg/ml against mouse red blood cells
Cytotoxicity[Ref.29040295] No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID29040295

Physicochemical Properties

Residues25
SequenceFIAAIIGGLFSAGKAIHRLIRRRRR
Molecular Weight2849.435
Grand Average of Hydropathy0.272
Isoelectric Point12
Charge at pH 7.46.591
Secondary StructureHelix: 0.360, Turn: 0.160, Sheet: 0.240
Instability Index107.724
Aromaticity0.08

Similar Structure Search

Candidates based on structure

Address: No.2699 Qianjin Street, Changchun City, China. Zip Code: 130012. 苏ICP备2021057230号-1.