Basic Information

IDDRAMP20901
SequenceFIHHIIGGLFSVGKHIHRLIRRRRR
Length25
NameA12V/A15H
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.29040295] Gram-positive bacteria: Staphylococcus aureus (MIC=16 μg/ml; MBC=16 μg/ml), Methicillin-resistant Staphylococcus aureus (MIC=32 μg/ml; MBC=64 μg/ml);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=128 μg/ml; MBC=128 μg/ml);##Fungi: Candida albicans (MIC=128 μg/ml; MBC=128 μg/ml)
Hemolytic Activity[Ref.29040295] 0% haemolysis at 0.78 μg/ml, 10% haemolysis at 1.56 μg/ml, 55% haemolysis at 3.13 μg/ml, 85% haemolysis at 6.25 μg/ml, 98% haemolysis at 12.50 μg/ml, 100% haemolysis at 25.00 μg/ml against mouse red blood cells
Cytotoxicity[Ref.29040295] No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID29040295

Physicochemical Properties

Residues25
SequenceFIHHIIGGLFSVGKHIHRLIRRRRR
Molecular Weight3075.672
Grand Average of Hydropathy-0.232
Isoelectric Point12
Charge at pH 7.46.701
Secondary StructureHelix: 0.400, Turn: 0.160, Sheet: 0.080
Instability Index144.416
Aromaticity0.08

Similar Structure Search

Candidates based on structure

Address: No.2699 Qianjin Street, Changchun City, China. Zip Code: 130012. 苏ICP备2021057230号-1.