Basic Information

IDDRAMP18494
SequenceFIHHIIGGLFSAGKAIHRLIRRRRR
Length25
NameTP4
SourceOreochromis niloticus (Nile tilapia) (Tilapia nilotica)
ActivityAntibacterial, Antifungal, anticancer, wound healing, Anti-Gram+, Anti-Gram-, Antimicrobial
Pathogen[Ref.29040295] Gram-positive bacteria: Staphylococcus aureus (MIC=8 μg/ml; MBC=16 μg/ml), Methicillin-resistant Staphylococcus aureus (MIC=16 μg/ml; MBC=32 μg/ml);##Gram-negative bacterium: Pseudomonas aeruginosa (MIC=64 μg/ml; MBC=128 μg/ml);##Fungi: Candida albicans (MIC=128 μg/ml; MBC=128 μg/ml)
Hemolytic Activity[Ref.29040295] 2% hemolysis at 0.78 μg/ml, 5% hemolysis at 1.56 μg/ml, 45% hemolysis at 3.13 μg/ml, 85% hemolysis at 6.25 μg/ml, 98% hemolysis at 12.50 μg/ml, 100% hemolysis at 25.00 μg/ml against mouse red blood cell
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot L0CKG3
PDB 5H2S
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID29040295

Physicochemical Properties

Residues25
SequenceFIHHIIGGLFSAGKAIHRLIRRRRR
Molecular Weight2981.557
Grand Average of Hydropathy-0.128
Isoelectric Point12
Charge at pH 7.46.665
Secondary StructureHelix: 0.360, Turn: 0.160, Sheet: 0.160
Instability Index130.236
Aromaticity0.08

Similar Structure Search

Candidates based on structure

Address: No.2699 Qianjin Street, Changchun City, China. Zip Code: 130012. 苏ICP备2021057230号-1.