Basic Information

IDDRAMP20894
SequenceFIHHIIGGLFSAGKAIHRHHRRRRR
Length25
NameL19H/I20H
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.29040295] Gram-positive bacteria: Staphylococcus aureus (MIC=128 μg/ml; MBC=512 μg/ml);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=256 μg/ml; MBC>512 μg/ml);##Fungi: Candida albicans (MIC=128 μg/ml; MBC=128 μg/ml)
Hemolytic Activity[Ref.29040295] 10% haemolysis at 6.25 μg/ml, 13% haemolysis at 12.50 μg/ml, 16% haemolysis at 25.00 μg/ml, 40% haemolysis at 50.00 μg/ml, 85% haemolysis at 100.00 μg/ml, 100% haemolysis at 200.00 μg/ml against mouse red blood cells
Cytotoxicity[Ref.29040295] No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID29040295

Physicochemical Properties

Residues25
SequenceFIHHIIGGLFSAGKAIHRHHRRRRR
Molecular Weight3029.521
Grand Average of Hydropathy-0.716
Isoelectric Point12
Charge at pH 7.46.738
Secondary StructureHelix: 0.280, Turn: 0.160, Sheet: 0.120
Instability Index137.94
Aromaticity0.08

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