Basic Information

IDDRAMP02331
SequenceFFHHIFRGIVHVGKTIHKLVTG
Length22
NamePiscidin-2 (Pis-2; fish, chordates, animals)
SourceMorone chrysops (White bass)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-positive bacteria: Enterococcus faecalis (MIC=5-10 µM), E. faecalis (MIC=2.5-5 µM), Listeria monocytogenes (MIC=2.5-5 µM), Micrococcus luteus (MIC=10-20 µM), Staphylococcus aureus (MIC=1.25-2.5 µM), S. epidermidis (MIC=5-10 µM), S. saprophiticus (MIC=5-10 µM), S. xylosus (MIC>20 µM), Streptococcus agalactiae (MIC=1.25-2.5 µM), S. bovis (MIC=1.25-2.5 µM), S. equisimilis (MIC=2.5-5 µM), S. mitis (MIC=1.25-2.5 µM), Streptococcus pneumoniae (MIC=1.25-2.5 µM), Streptococcus pyogenes (MIC=1.25-2.5 µM), S. iniae KST740ak (MIC=1.25-2.5 µM), S. iniae KSTSi 6P (MIC=1.25-2.5 µM);##Gram-negative bacteria: Aeromonas hydrophila (MIC>20 µM), Burkholderia cepacia (MIC>20 µM), Vibrio cholera (MIC=2.5-5 µM), Escherichia coli (MIC=5-10 µM), Moraxella catarrhalis (MIC=2.5-5 µM), Neisseria gonorrhoeae (MIC>20 µM), Pseudomonas aeruginosa (MIC=5-10 µM), Enterobacter cloacae (MIC=10-20 µM), E. aerogenes (MIC=10-20 µM), Klebsiella pneumoniae (MIC=2.5-5 µM), K. oxytoca (MIC=5-10 µM), Salmonella choleraesuis (MIC=10-20 µM), Salmonella typhimurium (MIC=10-20 µM), S. arizonae (MIC=10-20 µM), Serratia marcescens (MIC>20 µM), Shigella flexneri (MIC=2.5-5 µM), S. sonnei (MIC=5-10 µM), Yersinia enterocolitica (MIC=2.5-5 µM).##Fungi: Neurospora crassa (MIC=1.56-3.12 µM), Aspergillus fumigatus (MIC=50-100 µM), Fusarium oxysporum (MIC=0.78-1.56 µM), F. culmorum (MIC=0.39-0.78 µM), Candida albicans (MIC=10-20 µM), C. glabrata (MIC=10-20 µM), C. lusitania (MIC=10-20 µM), C. tropicalis (MIC=10-20 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot Q8UUG2
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID11739390

Physicochemical Properties

Residues22
SequenceFFHHIFRGIVHVGKTIHKLVTG
Molecular Weight2544.009
Grand Average of Hydropathy0.482
Isoelectric Point11.166
Charge at pH 7.42.699
Secondary StructureHelix: 0.455, Turn: 0.136, Sheet: 0.045
Instability Index15.018
Aromaticity0.136

Similar Structure Search

Candidates based on structure

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