Basic Information

IDDRAMP02366
SequenceGWKKWFTKGERLSQRHFA
Length18
NamePleurocidin-like peptide GC3.2 (NRC-18; fish, chordates, animals; Predicted)
SourceGlyptocephalus cynoglossus (Witch flounder GC3.2)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-negative bacteria: Aeromonas salmonicida 99-1 (MIC>64 µg/ml), A. salmonicida 97-4 (MIC=128 µg/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=32 µg/ml), S. enterica serovar Typhimurium 14028s (MIC>64 µg/ml), Pseudomonas aeruginosa K799 (MIC>64 µg/ml), Pseudomonas aeruginosa Z61 (MIC=64 µg/ml), Escherichia coli CGSC 4908 (MIC=64 µg/ml), E. coli UB1005 (MIC=64 µg/ml), E. coli DC2 (MIC=64 µg/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC>64 µg/ml), Staphylococcus aureus (MRSA) C623 (MIC>64 µg/ml).##Yeast: Candida albicans C627 (MIC>64 µg/ml).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot Q7SZG7
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID12878506

Physicochemical Properties

Residues18
SequenceGWKKWFTKGERLSQRHFA
Molecular Weight2262.573
Grand Average of Hydropathy-1.322
Isoelectric Point11.097
Charge at pH 7.43.588
Secondary StructureHelix: 0.278, Turn: 0.167, Sheet: 0.167
Instability Index23.033
Aromaticity0.222

Similar Structure Search

Candidates based on structure

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