Basic Information

IDDRAMP29058
SequenceKGLLRKWGKKWKEFLRRVW
Length19
NameP6.2
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.31778756] Gram-negative bacteria: P. aeruginosa (MIC = 16 μg/mL, MBC = 32 μg/mL); ##Gram-positive bacteria: S. aureus (MIC = 32 µg/mL, MBC = 128 μg/mL)
Hemolytic Activity[Ref.31778756]P6.2 exhibited a concentration dependent hemolytic activity, reaching values of 30% at the highest concentration(1024 μg/mL), but remaining below 5% until 128 μg/ml, which is fourfold or eightfold the MIC obtained for S.aureus or P.aeruginosa, respectively.
CytotoxicityNot found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID31778756

Physicochemical Properties

Residues19
SequenceKGLLRKWGKKWKEFLRRVW
Molecular Weight2515.058
Grand Average of Hydropathy-1.137
Isoelectric Point11.754
Charge at pH 7.46.546
Secondary StructureHelix: 0.421, Turn: 0.105, Sheet: 0.211
Instability Index45.5
Aromaticity0.211

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