Basic Information

IDDRAMP04336
SequenceIGKEFKRIVQRIKDFLRNL
Length19
NameIG-19 (residues 13-31 of LL-37)
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.22521196] Gram-positive bacteria : Bacillus subtilis (KCTC 3068)(MIC=4 μM), Staphylococcus epidermidis (KCTC 1917)(MIC=4 μM), Staphylococcus aureus (KCTC 1621)(MIC=4 μM);##Gram-negative bacteria : Escherichia coli (KCTC 1682)(MIC=8 μM), Pseudomonas aeruginosa (KCTC 1637)(MIC=16 μM), Salmonella typhimurium (KCTC 1926)(MIC=8 μM)
Hemolytic Activity[Ref.22521196] MHC10=21.6 μM against human red blood cells
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22521196

Physicochemical Properties

Residues19
SequenceIGKEFKRIVQRIKDFLRNL
Molecular Weight2373.84
Grand Average of Hydropathy-0.458
Isoelectric Point11
Charge at pH 7.43.551
Secondary StructureHelix: 0.421, Turn: 0.105, Sheet: 0.158
Instability Index17.979
Aromaticity0.105

Similar Structure Search

Candidates based on structure

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