ABPDB

Basic Information

ID	DRAMP29070
Sequence	GFGSLLGKALRLWKKVL
Length	17
Name	CPF-13 (Variant of CPF-C1)
Source	Synthetic construct
Activity	Antimicrobial, Antibacterial, Anti-Gram+
Pathogen	[Ref.32590058] Gram-positive: S. aureus ATCC 25923 (MIC = 4 μg/mL, MIC = 8 μg/mL in 10% serum, MIC = 4 μg/mL in 150 mM, MBIC50 = 4 μg/mL, MBIC90 = 8 μg/mL, MBEC = 8 μg/mL), MRSA ATCC 33591 (MIC = 8 μg/mL), MRSA 054 isolated from clinics (MIC = 8 μg/mL), MRSA 023 isolated from clinics (MIC = 8 μg/mL), MRSA 113 isolated from clinics (MIC = 8 μg/mL), MRSA 048 isolated from clinics (MIC = 8 μg/mL), MRSA 002 isolated from clinics (MIC = 8 μg/mL), MRSA 074 isolated from clinics (MIC = 8 μg/mL), MRSA 051 isolated from clinics (MIC = 8 μg/mL), MRSA 052 isolated from clinics (MIC = 8 μg/mL), MRSA 075 isolated from clinics (MIC = 8 μg/mL), MRSA 071 isolated from clinics (MIC = 8 μg/mL), MRSA 936 isolated from clinics (MIC = 8 μg/mL), S. aureus 725 (MIC = 8 μg/mL), S. aureus 794 (MIC = 8 μg/mL)
Hemolytic Activity	[Ref.32590058]It showed significant toxicity at high concentrations. At the concentration of 16, 32, 64 and 128 μg/mL, CPF-13 displayed 2%, 10%, 72% and 72% hemolysis, respectively.
Cytotoxicity	Not found
N-terminal Modification	Free
C-terminal Modification	Amidation
Linear/Cyclic/Branched	Linear
Uniprot
PDB
3D View
PDB Download	Download PDB Predicted by Alphafold2
PubMed ID	32590058

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