Basic Information

IDDRAMP01411
SequenceGILSGLLGVGKMLVCGLSGLC
Length21
NameNigrocin-OR3 (Frogs, amphibians, animals)
SourceOdorrana rotodora (Chinese odorous frogs)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3 µM), Bacillus pyocyaneus CMCCB 10104 (MIC=6 µM);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6 µM).##Yeast: Candida albicans ATCC 2002 (MIC=3 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys15 and Cys21)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22029824

Physicochemical Properties

Residues21
SequenceGILSGLLGVGKMLVCGLSGLC
Molecular Weight1990.497
Grand Average of Hydropathy1.652
Isoelectric Point8.058
Charge at pH 7.40.506
Secondary StructureHelix: 0.429, Turn: 0.381, Sheet: 0.333
Instability Index22.09
Aromaticity0

Similar Structure Search

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