Basic Information

IDDRAMP02409
SequenceGCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF
Length34
NameM-theraphotoxin-Gr1a (M-TRTX-Gr1a; GsMTx-4)
SourceGrammostola rosea (Chilean rose tarantula) (Grammostola spatulata)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
PathogenGram-positive bacteria: Bacillus subtilis (MIC=0.5 µM), Staphylococcus aureus (MIC=2-4 µM), Staphylococcus epidermidis (MIC=4-8 µM);##Gram-negative bacteria: Salmonella typhimurium (MIC=32.64 µM), Pseudomonas aeruginosa (MIC=8-16 µM), Escherichia coli (MIC=8-16 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedCyclic
Uniprot Q7YT39, Q7M3T1
PDB 1LU8, 1TYK
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed IDPubMed ID is not available, 12082099, 10779316, 163768

Physicochemical Properties

Residues34
SequenceGCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF
Molecular Weight4102.87
Grand Average of Hydropathy-0.426
Isoelectric Point8.886
Charge at pH 7.43.397
Secondary StructureHelix: 0.294, Turn: 0.235, Sheet: 0.147
Instability Index-1.138
Aromaticity0.176

Similar Structure Search

Candidates based on structure

Address: No.2699 Qianjin Street, Changchun City, China. Zip Code: 130012. 苏ICP备2021057230号-1.