Basic Information

IDDRAMP02603
SequenceAALRGALRAVARVGKAILPHVAIANPYVRTPYVHNNP
Length37
NamePutative antimicrobial peptide A Northern Europe Heligoland (chordates, animals)
SourceCiona intestinalis
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-positive bacteria: Bacillus megaterium (MIC=0.1 µM), Bacillus subtilis (MIC=3.1 µM), Staphylococcus aureus (MIC>25 µM), Staphylococcus epidermidis (MIC=25 µM).##Gram-negative bacteria: Escherichia coli K12 D31 (MIC=0.8 µM), Y. enterocolitica (MIC=3.1 µM), Klebsiella pneumoniae (MIC>25µM), Pseudomonas aeruginosa (MIC=12.5 µM), Serratia marcescens(MIC>25 µM).##Fungi: Candida albicans ATCC 10261 (MIC=6.3 µM), Candida albicans SC 5314 (MIC=6.3 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID17658598

Physicochemical Properties

Residues37
SequenceAALRGALRAVARVGKAILPHVAIANPYVRTPYVHNNP
Molecular Weight3947.597
Grand Average of Hydropathy0.176
Isoelectric Point11.568
Charge at pH 7.44.673
Secondary StructureHelix: 0.324, Turn: 0.243, Sheet: 0.297
Instability Index26.216
Aromaticity0.054

Similar Structure Search

Candidates based on structure

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