Basic Information

IDDRAMP02956
SequenceSHQDCYEALHKCMASHSKPFSCSMKFHMCLQQQ
Length33
NameDolabellanin B2
SourceDolabella auricularia (Sea hare)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-positive bacteria: Bacillus subtilis RIMD0225014 (MIC=2.5 µg/ml), Staphylococcus aureus IID1677 (MRSA) (MIC=20.0 µg/ml), Listeria monocytogenes VIU206 (MIC=40.0 µg/ml).##Gram-negative bacteria: Haemophilus influenzae IID983 (MIC=5.0 µg/ml), V. vulnificus RIMD2219009 (MIC=5.0 µg/ml), Escherichia coli JM109 (MIC=20.0 µg/ml), E. coli DH5α (MIC=40.0 µg/ml).##Fungi: Candida albicans ATCC36232, Candida tropicalis TIMM0313, S. pombe IFO1628, Saccharomyces cerevisiae A581A.
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedCyclic
Uniprot P83376
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID12590964

Physicochemical Properties

Residues33
SequenceSHQDCYEALHKCMASHSKPFSCSMKFHMCLQQQ
Molecular Weight3872.461
Grand Average of Hydropathy-0.603
Isoelectric Point7.711
Charge at pH 7.40.293
Secondary StructureHelix: 0.152, Turn: 0.182, Sheet: 0.242
Instability Index74.861
Aromaticity0.091

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