Basic Information

IDDRAMP03041
SequenceFDIMGLIKKVAGAL
Length14
NameEumenine mastoparan-ER (EMP-ER; Insects, animals)
SourceEumenes rubrofemoratus (Solitary wasp)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.21549739]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=30 µM), Staphylococcus epidermidis (clinical sample) (MIC=30 µM), Micrococcus luteus ATCC 10240 (MIC>30 µM), Streptococcus pyogenes (clinical sample) (MIC>30 µM), Bacillus subtilis ATCC 6633 (MIC=30 µM);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30 µM), Proteus mirabilis (clinical sample) (MIC=60 µM), Pseudomonas aeruginosa ATCC 27853 (MIC>30 µM), Stenotrophomonas maltophilia ATCC 13637 (MIC>30 µM);##Fungi: Candida albicans ATCC 90112 (MIC=7.5 µM).
Hemolytic Activity[Ref.21549739]EC50=200 μM against mice erythrocytes
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P0CJ38
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID21549739

Physicochemical Properties

Residues14
SequenceFDIMGLIKKVAGAL
Molecular Weight1475.837
Grand Average of Hydropathy1.214
Isoelectric Point8.591
Charge at pH 7.40.553
Secondary StructureHelix: 0.429, Turn: 0.143, Sheet: 0.357
Instability Index-0.093
Aromaticity0.071

Similar Structure Search

Candidates based on structure

Address: No.2699 Qianjin Street, Changchun City, China. Zip Code: 130012. 苏ICP备2021057230号-1.