Basic Information

IDDRAMP03120
SequenceATCDLASFSSQWVTPNDSLCAAHCLVKGYRGGYCKNKICHCRDKF
Length45
NameDef-BBB (hybrid defensins; Insects, animals)
SourceAnopheles gambiae (African malaria mosquito)
ActivityAntimicrobial, Antibacterial, Anti-Gram+
PathogenGram-positive bacteria: Staphylococcus aureus strain 21 (IC90=10 µg/mL), Staphylococcus aureus strain 4 (IC90>80 µg/mL).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot Q17027
PDB 2E3E
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID18214975

Physicochemical Properties

Residues45
SequenceATCDLASFSSQWVTPNDSLCAAHCLVKGYRGGYCKNKICHCRDKF
Molecular Weight4998.702
Grand Average of Hydropathy-0.24
Isoelectric Point8.643
Charge at pH 7.42.52
Secondary StructureHelix: 0.244, Turn: 0.222, Sheet: 0.156
Instability Index25.049
Aromaticity0.111

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